Private: Careers (old)

Private: Careers (old)

We are seeking extraordinary
and ambitious individuals
who share our drive and
desire to transform medicine

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Senior Scientist – Process Research & Development

CMC: We are seeking a Senior Scientist – Process Research & Development to provide technical expertise to drive the process development and manufacturing of a novel nanoparticle, and the coupling of a recombinant pMHC protein to the nanoparticle, to produce active drug substances (referred to as a Navacim).  The role requires expertise in organic and protein chemistry, preferably with experience in nanoparticles, bioconjugation and/or nanomedicines.  The Senior Scientist will develop and scale-up robust manufacturing processes to produce material for pre-GMP and clinical studies to support the Parvus therapeutic platform.  This includes building a strong technical understanding of the process chemistry and its influence on the molecular characteristics of these novel therapeutic constructs.  The role will then provide technical oversight to the manufacturing conjugation process at the CMO and follow batches through release and stability testing.  The individual must also work closely with other CMC functions in Parvus to ensure timely support to, and alignment with, formulation and analytical development activities and stability studies. This position reports toVice President – Process Sciences and Manufacturing.  Compensation and title will be commensurate with experience level.

Location: South San Francisco, CA

Parvus Therapeutics is pioneering a breakthrough class of disease-specific, non-immunosuppressive biologics called NavacimsTM  that are designed to halt and potentially cure autoimmune disease and other inflammatory disorders by restoring immune tolerance. The Navacim technology platform is generating a rich pipeline of therapeutic candidates to address a wide range of inflammatory diseases. Our most advanced programs target Type 1 Diabetes (T1D) (partnered with Novartis) and autoimmune liver diseases.  POC and efficacy in animals has been established not only for these two programs but also for multiple sclerosis (MS) and inflammatory bowel disease (IBD).

Drug candidates have also been identified for celiac disease with others in earlier stages of research. Parvus recently announced that it had entered into a worldwide collaboration and license agreement with Genentech covering three of these programs: autoimmune liver, IBD, and celiac.  In support of our new partnership, Parvus is expanding rapidly to on-board the additional resources necessary to advance these programs to the clinic.

The Parvus management team combines decades of experience in start-ups and biopharma, with demonstrated success in commercializing drugs from the lab to the market. We are seeking extraordinary and ambitious individuals who share our drive and desire to transform medicine.

Responsibilities:

Required Skills/Experience:   

Parvus Therapeutics is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Parvus is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment.

(Req # 1200-45)

No relocation offered-local candidates only